Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX3CR1+ Macrophages in Tissue Repair

Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX3CR1+ Macrophages in Tissue Repair

Arthritogenic alphaviruses cause debilitating inflammatory disease, and current therapies are restricted to palliative approaches. Here, we show that following monocyte-driven muscle inflammation, tissue recovery is associated with the accumulation of CX3CR1+ macrophages in the muscle. Modulating in...

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Bibliographic Details
Main Authors: Ali Zaid, Kothila Tharmarajah, Helen Mostafavi, Joseph R. Freitas, Kuo-Ching Sheng, Suan-Sin Foo, Weiqiang Chen, Jelena Vider, Xiang Liu, Nicholas P. West, Lara J. Herrero, Adam Taylor, Laura K. Mackay, Daniel R. Getts, Nicholas J. C. King, Suresh Mahalingam
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
inflammation
macrophages
microparticles
myositis
ross river virus
tissue repair
viral infection
Online Access:https://doi.org/10.1128/mBio.03353-19

Internet

https://doi.org/10.1128/mBio.03353-19

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