β-Amyloid Peptides Are Cytotoxic to Astrocytes in Culture: A Role for Oxidative Stress
β-Amyloid is cytotoxic to neurons in culture by increasing hydrogen peroxide and altering calcium homeostasis. We have evaluated the cytotoxicty of β-amyloid peptides (βA25–35 and βA1–40) and generation of hydrogen peroxide on cortical cultured astrocytes. Twenty-four hours after a single addition o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2000-08-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996100903139 |