Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.

Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.

OBJECTIVE:We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology. METHODS:Del1 KO and WT mice had cartilage thickn...

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Bibliographic Details
Main Authors: Zhen Wang, Misha C Tran, Namrata J Bhatia, Alexander W Hsing, Carol Chen, Marie F LaRussa, Ernst Fattakhov, Vania Rashidi, Kyu Yun Jang, Kevin J Choo, Xingju Nie, Jonathan A Mathy, Michael T Longaker, Reinhold H Dauskardt, Jill A Helms, George P Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4978450?pdf=render

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http://europepmc.org/articles/PMC4978450?pdf=render

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