Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis

Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis

Abstract Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics. One of the methods usually used for characterization and quantification of biopharmaceu...

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Bibliographic Details
Main Authors: Juraj Piestansky, Jaroslav Galba, Dominika Olesova, Branislav Kovacech, Andrej Kovac
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Chemistry
Subjects:
Amino acids
Ultra high-performance chromatography
Mass spectrometry
Derivatization
Biopharmaceuticals
Keyhole limpet hemocyanin
Online Access:http://link.springer.com/article/10.1186/s13065-019-0581-z

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http://link.springer.com/article/10.1186/s13065-019-0581-z

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