Aβ and inflammatory stimulus activate diverse signaling pathways in monocytic cells: implications in retaining phagocytosis in Aβ-laden environment

Aβ and inflammatory stimulus activate diverse signaling pathways in monocytic cells: implications in retaining phagocytosis in Aβ-laden environment

Background Accumulation of amyloid β (Aβ) is one of the main hallmarks of Alzheimer’s disease (AD). The enhancement of Aβ clearance may provide therapeutic means to restrict AD pathology. The cellular responses to different forms of Aβ in monocytic cells are poorly known. We aimed to study whether d...

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Bibliographic Details
Main Authors: Ekaterina Savchenko, Tarja Malm, Henna Konttinen, Riikka H Hamalainen, Cindy Guerrero-Toro, Sara Wojciechowski, Rashid Giniatullin, Jari Koistinaho, Johanna Magga
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Bone Marrow
Calcium
Cytokines
Hematopoietic Stem Cells
Monocytes
Phagocytosis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00279/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00279/full

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