HIV-1 entry and trans-infection of astrocytes involves CD81 vesicles.

Astrocytes are extensively infected with HIV-1 in vivo and play a significant role in the development of HIV-1-associated neurocognitive disorders. Despite their extensive infection, little is known about how astrocytes become infected, since they lack cell surface CD4 expression. In the present stu...

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Bibliographic Details
Main Authors: Lachlan R Gray, Stuart G Turville, Tina L Hitchen, Wan-Jung Cheng, Anne M Ellett, Hamid Salimi, Michael J Roche, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938779?pdf=render