Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence that islet epitope reactive T cells are prese...

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Bibliographic Details
Main Authors: Teresa Rodriguez-Calvo, Gustaf Christoffersson, Christine Bender, Matthias G. von Herrath, Roberto Mallone, Sally C. Kent, Eddie A. James
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
insulitis
autoreactive T cells
non-islet reactive T cells
β cell destruction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.683091/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.683091/full

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