Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

Objective: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. Methods: We expressed each FXR variant in primary hepatocytes and evaluate...

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Bibliographic Details
Main Authors: Jorge C. Correia, Julie Massart, Jan Freark de Boer, Margareta Porsmyr-Palmertz, Vicente Martínez-Redondo, Leandro Z. Agudelo, Indranil Sinha, David Meierhofer, Vera Ribeiro, Marie Björnholm, Sascha Sauer, Karin Dahlman-Wright, Juleen R. Zierath, Albert K. Groen, Jorge L. Ruas
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Molecular Metabolism
Subjects:
FXR isoforms
Splicing
NAFLD
Insulin resistance
Energy metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001751

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http://www.sciencedirect.com/science/article/pii/S2212877815001751

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