Lentiviral vector mediated thymidine kinase expression in pluripotent stem cells enables removal of tumorigenic cells.

Embryonic stem cells (ES) and induced pluripotent stem (iPS) cells represent promising tools for cell-based therapies and regenerative medicine. Nevertheless, implantation of ES cell derived differentiated cells holds the risk of teratoma formation due to residual undifferentiated cells. In order to...

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Bibliographic Details
Main Authors: Tiong-Ti Lim, Caroline Geisen, Michael Hesse, Bernd K Fleischmann, Katrin Zimmermann, Alexander Pfeifer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728319?pdf=render