Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1

Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1

The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs). Here, we identify transient overexpression of the transcription factor (TF) NKX2-1 a...

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Bibliographic Details
Main Authors: Keri Dame, Steven Cincotta, Alex H. Lang, Reeti M. Sanghrajka, Liye Zhang, Jinyoung Choi, Letty Kwok, Talitha Wilson, Maciej M. Kańduła, Stefano Monti, Anthony N. Hollenberg, Pankaj Mehta, Darrell N. Kotton, Laertis Ikonomou
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Stem Cell Reports
Subjects:
mouse embryonic stem cell
pluripotent stem cell
directed differentiation
thyroid development
Nkx2-1
transcription factor
overexpression
progenitor specification
foregut
inducible
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116303149

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http://www.sciencedirect.com/science/article/pii/S2213671116303149

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