Combination of Aβ Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC

Combination of Aβ Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC

Repair of oxidative DNA damage, particularly Base Excision Repair (BER), impairment is often associated with Alzheimer’s disease pathology. Here, we aimed at investigating the complete Nucleotide Excision Repair (NER), a DNA repair pathway involved in the removal of bulky DNA adducts, status in an A...

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Bibliographic Details
Main Authors: Anne Forestier, Thierry Douki, Viviana De Rosa, David Béal, Walid Rachidi
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
neurodegenerative disorders
Alzheimer’s disease
DNA damage
DNA repair
nucleotide excision repair
XPC
DDB2
oxidative stress
Online Access:http://www.mdpi.com/1422-0067/16/8/17422

Internet

http://www.mdpi.com/1422-0067/16/8/17422

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