SIRT6 is a DNA double-strand break sensor

SIRT6 is a DNA double-strand break sensor

DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independently of signaling and known sensors. It activates do...

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Bibliographic Details
Main Authors: Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
SIRT6
DNA damage
sensor
DSB
DNA repair
Online Access:https://elifesciences.org/articles/51636

Internet

https://elifesciences.org/articles/51636

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