In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients

In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients

Influenza A(H1N1)pdm09 viruses carrying a dual neuraminidase (NA) substitution were isolated from immunocompromised patients after administration of one or more NA inhibitors. These mutant viruses possessed an H275Y/I223R, H275Y/I223K, or H275Y/G147R substitution in their NA and showed enhanced cros...

Full description

Bibliographic Details
Main Authors: Emi Takashita, Seiichiro Fujisaki, Masaru Yokoyama, Masayuki Shirakura, Hiroko Morita, Kazuya Nakamura, Noriko Kishida, Tomoko Kuwahara, Hironori Sato, Ikuko Doi, Yuji Sato, Shinichi Takao, Yukie Shimazu, Takeshi Shimomura, Takuo Ito, Shinji Watanabe, Takato Odagiri, The Influenza Virus Surveillance Group of Japan
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pathogens
Subjects:
influenza
neuraminidase inhibitor
oseltamivir
peramivir
zanamivir
laninamivir
Online Access:https://www.mdpi.com/2076-0817/9/9/725

Internet

https://www.mdpi.com/2076-0817/9/9/725

Similar Items