Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

Summary: Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor metabolic health, and BAT reactivation may confer t...

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Bibliographic Details
Main Authors: Christian Schlein, Alexander W. Fischer, Frederike Sass, Anna Worthmann, Klaus Tödter, Michelle Y. Jaeckstein, Janina Behrens, Matthew D. Lynes, Michael A. Kiebish, Niven R. Narain, Val Bussberg, Abena Darkwah, Naja Zenius Jespersen, Søren Nielsen, Camilla Scheele, Michaela Schweizer, Ingke Braren, Alexander Bartelt, Yu-Hua Tseng, Joerg Heeren, Ludger Scheja
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
brown adipose tissue
de novo lipogenesis
ChREBP
fatty acid synthesis
mitochondria
mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316132

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http://www.sciencedirect.com/science/article/pii/S2211124720316132

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