Quantitative Proteomics to Characterize Specific Histone H2A Proteolysis in Chronic Lymphocytic Leukemia and the Myeloid THP-1 Cell Line

Quantitative Proteomics to Characterize Specific Histone H2A Proteolysis in Chronic Lymphocytic Leukemia and the Myeloid THP-1 Cell Line

Proteome studies on hematological malignancies contribute to the understanding of the disease mechanism and to the identification of new biomarker candidates. With the isobaric tag for relative and absolute quantitation (iTRAQ) method we analyzed the protein expression between B-cells of healthy peo...

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Bibliographic Details
Main Authors: Pieter Glibert, Liesbeth Vossaert, Katleen Van Steendam, Stijn Lambrecht, Filip Van Nieuwerburgh, Fritz Offner, Thomas Kipps, Maarten Dhaenens, Dieter Deforce
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
histone H2A
proteolysis
histone clipping
chronic lymphocytic leukemia
THP-1 cells
quantitative proteomics
Online Access:http://www.mdpi.com/1422-0067/15/6/9407

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http://www.mdpi.com/1422-0067/15/6/9407

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