Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo.

Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo.

Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another small molecule, ferristatin II (NSC8679), acts in a similar manner to degrad...

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Bibliographic Details
Main Authors: Shaina L Byrne, Peter D Buckett, Jonghan Kim, Flora Luo, Jack Sanford, Juxing Chen, Caroline Enns, Marianne Wessling-Resnick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720890?pdf=render

Internet

http://europepmc.org/articles/PMC3720890?pdf=render

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