Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients

Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients

Abstract Background Multi-organ failure occurs during critical illness and is mediated in part by destructive neutrophil-to-endothelial interactions. The β2 integrin receptor, CR3 (complement receptor 3; Mac-1; CD11b/CD18), which binds endothelial intercellular adhesion molecule-1 (ICAM-1), plays a...

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Bibliographic Details
Main Authors: Catherine M. Dickinson, Brian W. LeBlanc, Muhammad M. Edhi, Daithi S. Heffernan, Mohd. Hafeez Faridi, Vineet Gupta, William G. Cioffi, Xian O’Brien, Jonathan S. Reichner
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Intensive Care
Subjects:
Neutrophil
Endothelium
Barrier function
Sepsis
Trauma
Leukadherin-1
Online Access:http://link.springer.com/article/10.1186/s40560-018-0289-5

Internet

http://link.springer.com/article/10.1186/s40560-018-0289-5

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