Docking-based strategy to design novel flavone-based arylamides as potent V600E-BRAF inhibitors with prediction of their drug-likeness and ADMET properties

Docking-based strategy to design novel flavone-based arylamides as potent V600E-BRAF inhibitors with prediction of their drug-likeness and ADMET properties

Abstract Background V600E-BRAF protein target has much potential for scientific research as therapeutic target due to its involvement in human melanoma cancer. In the current research, molecular docking investigation was conducted on some flavone-based arylamides as anticancer drug candidates via V6...

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Bibliographic Details
Main Authors: Abdullahi Bello Umar, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:Bulletin of the National Research Centre
Subjects:
Melanoma
V600E-BRAF
Virtual screening
Docking simulation
ADMET
Online Access:http://link.springer.com/article/10.1186/s42269-020-00432-7

Internet

http://link.springer.com/article/10.1186/s42269-020-00432-7

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