Targeting CD276 by CAR-T cells induces regression of esophagus squamous cell carcinoma in xenograft mouse models

Targeting CD276 by CAR-T cells induces regression of esophagus squamous cell carcinoma in xenograft mouse models

Esophageal cancer, including esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), has a poor prognosis and limited therapeutic options. Chimeric antigen receptor (CAR)-T cells represent a potential ESCC treatment. In this study, we examined CD276 expression in healthy and e...

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Bibliographic Details
Main Authors: Yujing Xuan, Yuqiao Sheng, Daiqun Zhang, Kai Zhang, Zhen Zhang, Yu Ping, Shumin Wang, Xiaojuan Shi, Jingyao Lian, Kangdong Liu, Yi Zhang, Feng Li
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Translational Oncology
Subjects:
Esophageal cancer
CD276
CAR-T cell
Co-stimulation
Patient-derived xenograft
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001303

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http://www.sciencedirect.com/science/article/pii/S1936523321001303

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