Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.

Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.

It has been established that Hsp60 can accumulate in the cytosol in various pathological conditions, including cancer and chronic inflammatory diseases. Part or all of the cytosolic Hsp60 could be naïve, namely, bear the mitochondrial import signal (MIS), but neither the structure nor the in solutio...

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Bibliographic Details
Main Authors: Silvia Vilasi, Rita Carrotta, Maria Rosalia Mangione, Claudia Campanella, Fabio Librizzi, Loredana Randazzo, Vincenzo Martorana, Antonella Marino Gammazza, Maria Grazia Ortore, Annalisa Vilasi, Gabriella Pocsfalvi, Giosalba Burgio, Davide Corona, Antonio Palumbo Piccionello, Giovanni Zummo, Donatella Bulone, Everly Conway de Macario, Alberto J L Macario, Pier Luigi San Biagio, Francesco Cappello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4022648?pdf=render

Internet

http://europepmc.org/articles/PMC4022648?pdf=render

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