Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA double-strand breaks. Through the use of an unbiased ge...

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Bibliographic Details
Main Authors: Madeleine Bossaert, Angélique Pipier, Jean-Francois Riou, Céline Noirot, Linh-Trang Nguyên, Remy-Felix Serre, Olivier Bouchez, Eric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gomez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
G-quadruplex
CX-5461
topoisomerase 2
DNA breaks
transcription
Online Access:https://elifesciences.org/articles/65184

Internet

https://elifesciences.org/articles/65184

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