Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.

Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.

<h4>Background</h4>Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.<h4>Methodology/principal findings</h4>Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergi...

Full description

Bibliographic Details
Main Authors: Déborah Tribouillard-Tanvier, Vincent Béringue, Nathalie Desban, Fabienne Gug, Stéphane Bach, Cécile Voisset, Hervé Galons, Hubert Laude, Didier Vilette, Marc Blondel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18431471/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18431471/pdf/?tool=EBI

Similar Items