CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D

CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D

During normal pregnancy, the placental trophoblast secretes a variety of steroid hormones and participates in the regulation of maternal physiological functions and fetal development. The CYP11A1 gene encodes the cholesterol side-chain cleavage enzyme P450scc, which catalyzes the production of pregn...

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Bibliographic Details
Main Authors: Xiang Wang, Mengxue Li, Xueguang Zhang, Yaqian Li, Guolin He, Andras Dinnyés, Qun Sun, Wenming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
CYP11A1
P450scc
neuronal stem cells
trophoblast
vitamin D
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.608447/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.608447/full

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