ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

Abstract Background Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. Methods MDA-MB...

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Bibliographic Details
Main Authors: Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, liwen Shen, Jingshan Shi, Ning Gao
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ROCK1
Cofilin
Drp1
Arnidiol
Mitochondrial fission
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13046-020-01545-7

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http://link.springer.com/article/10.1186/s13046-020-01545-7

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