PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

Abstract Background Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling evidence to causatively link specific PINK1/parki...

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Bibliographic Details
Main Authors: Sheila K. Pirooznia, Changqing Yuan, Mohammed Repon Khan, Senthilkumar S. Karuppagounder, Luan Wang, Yulan Xiong, Sung Ung Kang, Yunjong Lee, Valina L. Dawson, Ted M. Dawson
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Neurodegeneration
Subjects:
PARIS
ZNF746
Parkin
PINK1
Mitochondria
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-020-00363-x

Internet

http://link.springer.com/article/10.1186/s13024-020-00363-x

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