Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems.

Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems.

Certain microbes invade brain microvascular endothelial cells (BMECs) to breach the blood-brain barrier (BBB) and establish central nervous system (CNS) infection. Here we use the leading meningitis pathogen group B Streptococcus (GBS) together with insect and mammalian infection models to probe a p...

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Bibliographic Details
Main Authors: Yung-Chi Chang, Zhipeng Wang, Lindsay A Flax, Ding Xu, Jeffrey D Esko, Victor Nizet, Miriam J Baron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3121876?pdf=render

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http://europepmc.org/articles/PMC3121876?pdf=render

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