Impact of combined clenbuterol and metoprolol therapy on reverse remodelling during mechanical unloading.

Clenbuterol (Cl), a β2 agonist, is associated with enhanced myocardial recovery during left ventricular assist device (LVAD) support, and exerts beneficial remodelling effects during mechanical unloading (MU) in rodent heart failure (HF). However, the specific effects of combined Cl+β1 blockade duri...

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Bibliographic Details
Main Authors: Manoraj Navaratnarajah, Urszula Siedlecka, Michael Ibrahim, Carin van Doorn, Gopal Soppa, Ajay Gandhi, Adarsh Shah, Punam Kukadia, Magdi H Yacoub, Cesare M Terracciano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4181979?pdf=render