Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts

Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts

The sphingosine kinase 1 (SPHK1)/sphingosine−1−phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice. Recent evidence implicates the involvement of the Hippo/Yes-assoc...

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Bibliographic Details
Main Authors: Long Shuang Huang, Tara Sudhadevi, Panfeng Fu, Prasanth-Kumar Punathil-Kannan, David Lenin Ebenezer, Ramaswamy Ramchandran, Vijay Putherickal, Paul Cheresh, Guofei Zhou, Alison W. Ha, Anantha Harijith, David W. Kamp, Viswanathan Natarajan
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
lung fibroblast
yap signaling
sphk1
s1p
tgf-β
pulmonary fibrosis
blm
Online Access:https://www.mdpi.com/1422-0067/21/6/2064

Internet

https://www.mdpi.com/1422-0067/21/6/2064

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