Signaling Pathway for Endothelin-1- and Phenylephrine-Induced cAMP Response Element Binding Protein Activation in Rat Ventricular Myocytes: Role of Inositol 1,4,5-Trisphosphate Receptors and CaMKII

Signaling Pathway for Endothelin-1- and Phenylephrine-Induced cAMP Response Element Binding Protein Activation in Rat Ventricular Myocytes: Role of Inositol 1,4,5-Trisphosphate Receptors and CaMKII

Background/Aims: Endothelin-1 (ET-1) and the α1-adrenoceptor agonist phenylephrine (PE) activate cAMP response element binding protein (CREB), a transcription factor implicated in cardiac hypertrophy. The signaling pathway involved in CREB activation by these hypertrophic stimuli is poorly understoo...

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Bibliographic Details
Main Authors: Krishna P. Subedi, Min-Jeong Son, Bojjibabu Chidipi, Seong-Woo Kim, Jun Wang, Kyeong-Hee Kim, Sun-Hee  Woo, Joon-Chul Kim
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
cAMP response element binding protein
Inositol 1,4,5-trisphosphate receptor
Protein kinase C
Ca2+-calmodulin-dependent protein kinase II
Ventricular myocytes
Online Access:http://www.karger.com/Article/FullText/456422

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http://www.karger.com/Article/FullText/456422

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