Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

The anti-tumor activity of diosgenin, a new steroidal constituent present in fenugreek, on two human breast cancer cell lines, MCF-7 and Hs578T, was studied. Diosgenin treatment resulted in cell growth inhibition, cell cycle arrest, and apoptosis in concentration- and time-dependent manners in both...

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Bibliographic Details
Main Authors: Wen-Ling Liao, Jing-Yi Lin, Jia-Ching Shieh, Hsiao-Fong Yeh, Yi-Hsien Hsieh, Yu-Chun Cheng, Huei-Jane Lee, Chen-Yang Shen, Chun-Wen Cheng
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
diosgenin
breast cancer
cell cycle
chk1
apoptosis
∆ψm
Online Access:https://www.mdpi.com/1422-0067/21/1/172

Internet

https://www.mdpi.com/1422-0067/21/1/172

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