Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

Developing noninvasive diagnostic biomarkers for lupus nephritis (LN) diagnosis is an important clinical goal. Here the authors identify urinary proteins correlated with active LN and disease severity, which differ across ethnicities but collectively outperform the current clinical method.

Bibliographic Details
Main Authors:	Samantha Stanley, Kamala Vanarsa, Samar Soliman, Deena Habazi, Claudia Pedroza, Gabriel Gidley, Ting Zhang, Shree Mohan, Evan Der, Hemant Suryawanshi, Thomas Tuschl, Jill Buyon, Chaim Putterman, Chi Chiu Mok, Michelle Petri, Ramesh Saxena, Chandra Mohan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15986-3

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spelling	doaj-8f0c56b51da44a74acb2b59ce3524af92021-05-11T08:31:38ZengNature Publishing GroupNature Communications2041-17232020-05-0111111310.1038/s41467-020-15986-3Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicitiesSamantha Stanley0Kamala Vanarsa1Samar Soliman2Deena Habazi3Claudia Pedroza4Gabriel Gidley5Ting Zhang6Shree Mohan7Evan Der8Hemant Suryawanshi9Thomas Tuschl10Jill Buyon11Chaim Putterman12Chi Chiu Mok13Michelle Petri14Ramesh Saxena15Chandra Mohan16Department Biomedical Engineering, University of HoustonDepartment Biomedical Engineering, University of HoustonDepartment Biomedical Engineering, University of HoustonDepartment Biomedical Engineering, University of HoustonCenter for Clinical Research and Evidence-Based Medicine, University of Texas Health Science Center at HoustonDepartment Biomedical Engineering, University of HoustonDepartment Biomedical Engineering, University of HoustonDepartment Biomedical Engineering, University of HoustonDepartment of Rheumatology, Albert Einstein College of MedicineDepartment of Molecular Biology, Rockefeller UniversityDepartment of Molecular Biology, Rockefeller UniversityDepartment of Rheumatology, New York UniversityDepartment of Rheumatology, Albert Einstein College of MedicineDepartment of Medicine, Tuen Mun HospitalDivision of Rheumatology, Johns Hopkins University School of MedicineUniversity Hospital Kidney & Liver Clinic, University of Texas Southwestern Medical CenterDepartment Biomedical Engineering, University of HoustonDeveloping noninvasive diagnostic biomarkers for lupus nephritis (LN) diagnosis is an important clinical goal. Here the authors identify urinary proteins correlated with active LN and disease severity, which differ across ethnicities but collectively outperform the current clinical method.https://doi.org/10.1038/s41467-020-15986-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Samantha Stanley Kamala Vanarsa Samar Soliman Deena Habazi Claudia Pedroza Gabriel Gidley Ting Zhang Shree Mohan Evan Der Hemant Suryawanshi Thomas Tuschl Jill Buyon Chaim Putterman Chi Chiu Mok Michelle Petri Ramesh Saxena Chandra Mohan
spellingShingle	Samantha Stanley Kamala Vanarsa Samar Soliman Deena Habazi Claudia Pedroza Gabriel Gidley Ting Zhang Shree Mohan Evan Der Hemant Suryawanshi Thomas Tuschl Jill Buyon Chaim Putterman Chi Chiu Mok Michelle Petri Ramesh Saxena Chandra Mohan Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities Nature Communications
author_facet	Samantha Stanley Kamala Vanarsa Samar Soliman Deena Habazi Claudia Pedroza Gabriel Gidley Ting Zhang Shree Mohan Evan Der Hemant Suryawanshi Thomas Tuschl Jill Buyon Chaim Putterman Chi Chiu Mok Michelle Petri Ramesh Saxena Chandra Mohan
author_sort	Samantha Stanley
title	Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
title_short	Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
title_full	Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
title_fullStr	Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
title_full_unstemmed	Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
title_sort	comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	Developing noninvasive diagnostic biomarkers for lupus nephritis (LN) diagnosis is an important clinical goal. Here the authors identify urinary proteins correlated with active LN and disease severity, which differ across ethnicities but collectively outperform the current clinical method.
url	https://doi.org/10.1038/s41467-020-15986-3
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Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

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