Quantitative structure–activity relationship study on potent anticancer compounds against MOLT-4 and P388 leukemia cell lines

Quantitative structure–activity relationship study on potent anticancer compounds against MOLT-4 and P388 leukemia cell lines

A quantitative structure–activity relationship (QSAR) study was carried out on 112 anticancer compounds to develop a robust model for the prediction of anti-leukemia activity (pGI50) against MOLT-4 and P388 leukemia cell lines. The Genetic algorithm (GA) and multiple linear regression analysis (MLRA...

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Bibliographic Details
Main Authors: David Ebuka Arthur, Adamu Uzairu, Paul Mamza, Stephen Abechi
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Journal of Advanced Research
Subjects:
QSAR method
Anticancer
paDEL descriptors
Applicability domain
Cell lines
NCI database
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123216300121

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http://www.sciencedirect.com/science/article/pii/S2090123216300121

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