The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1

The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1

FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunog...

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Bibliographic Details
Main Authors: Jessica C. Anania, Halina M. Trist, Catherine S. Palmer, Peck Szee Tan, Betty P. Kouskousis, Alicia M. Chenoweth, Stephen J. Kent, Graham A. Mackay, Alberta Hoi, Rachel Koelmeyer, Charlotte Slade, Vanessa L. Bryant, Philip D. Hodgkin, Pei Mun Aui, Menno C. van Zelm, Bruce D. Wines, P. Mark Hogarth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
Fc receptors
common variable immunodeficiency
immunodeficiency
systemic lupus erythematosus
immune complex
non-human primates
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01809/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01809/full

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