Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism

Hepatic iron deposition is seen in cases of chronic hepatitis and cirrhosis, and is a hallmark of a poorer prognosis. Iron deposition is also found in non-alcoholic steatohepatitis (NASH) patients. We have now developed a mouse model of NASH with hepatic iron deposition by combining a methione- and...

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Bibliographic Details
Main Authors: Akihiro Yamauchi, Akiko Kamiyoshi, Takayuki Sakurai, Hiroyuki Miyazaki, Eiichi Hirano, Hong-Seok Lim, Taiichi Kaku, Takayuki Shindo
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018379453