High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.

High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.

Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry. The polygenic nature of IgAD is underscored by the recent identification of several new risk gene...

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Bibliographic Details
Main Authors: Ricardo C Ferreira, Qiang Pan-Hammarström, Robert R Graham, Gumersindo Fontán, Annette T Lee, Ward Ortmann, Ning Wang, Elena Urcelay, Miguel Fernández-Arquero, Concepción Núñez, Gudmundur Jorgensen, Björn R Ludviksson, Sinikka Koskinen, Katri Haimila, Leonid Padyukov, Peter K Gregersen, Lennart Hammarström, Timothy W Behrens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3266887?pdf=render

Internet

http://europepmc.org/articles/PMC3266887?pdf=render

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