Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

Microglial activation is a key pathogenic process at the onset of Alzheimer’s disease (AD). Identifying regulators of microglial activation bears great potential in elucidating causes and mechanisms of AD and determining candidates for early intervention. Previous studies demonstrate abnormal elevat...

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Bibliographic Details
Main Authors: Ge Gao, Shu Zhao, Xiaohuan Xia, Chunhong Li, Congcong Li, Chenhui Ji, Shiyang Sheng, Yalin Tang, Jie Zhu, Yi Wang, Yunlong Huang, Jialin C. Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
glutaminase C
microglia activation
brain inflammation
glutaminase inhibitor
exosome
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00264/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00264/full

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