The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro

The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro

Although metabolic pathways have been shown to control differentiation and activation in peripheral T cells, metabolic studies on thymic T cell development are still lacking, especially in human tissue. In this study, we use transcriptomics and extracellular flux analyses to investigate the metaboli...

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Bibliographic Details
Main Authors: Victoria Sun, Mark Sharpley, Karolina E. Kaczor-Urbanowicz, Patrick Chang, Amélie Montel-Hagen, Shawn Lopez, Alexandre Zampieri, Yuhua Zhu, Stéphanie C. de Barros, Chintan Parekh, David Casero, Utpal Banerjee, Gay M. Crooks
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
thymus
metabolism
T cell
organoid
thymopoiesis
human
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.716661/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.716661/full

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