A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

Abstract Background Efforts to elucidate the function of enhancers in vivo are underway but their vast numbers alongside differing enhancer architectures make it difficult to determine their impact on gene activity. By systematically annotating multiple mouse tissues with super- and typical-enhancer...

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Bibliographic Details
Main Authors: Siddharth Sethi, Ilya E. Vorontsov, Ivan V. Kulakovskiy, Simon Greenaway, John Williams, Vsevolod J. Makeev, Steve D. M. Brown, Michelle M. Simon, Ann-Marie Mallon
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Genomics
Subjects:
Super-enhancers
Typical-enhancers
Tissue-specificity
Expression
Phenotypes
Protein-protein interactions
Online Access:http://link.springer.com/article/10.1186/s12864-020-07109-5

Internet

http://link.springer.com/article/10.1186/s12864-020-07109-5

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