IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt

IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt

Background: Psoriatic arthritis (PsA) is a chronic inflammatory joint disease within the spondyloarthritis spectrum. IL-12p40/IL-23p40 blockade reduces PsA disease activity, but its impact on synovial inflammation remains unclear.Objectives: To investigate the cellular and molecular pathways affecte...

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Bibliographic Details
Main Authors: Renée H. Fiechter, Henriëtte M. de Jong, Leonieke J. J. van Mens, Inka A. Fluri, Sander W. Tas, Dominique L. P. Baeten, Nataliya G. Yeremenko, Marleen G. H. van de Sande
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
psoriatc arthritis
synovium
spondyarthropathies
ustekinumab
PI3K - AKT pathway
MAPK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.611656/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.611656/full

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