Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.

Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.

Human immunodeficiency virus (HIV-1) is, like most pathogens, under selective pressure to escape the immune system of its host. In particular, HIV-1 can avoid recognition by cytotoxic T lymphocytes (CTLs) by altering the binding affinity of viral peptides to human leukocyte antigen (HLA) molecules,...

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Bibliographic Details
Main Authors: Rafal Mostowy, Roger D Kouyos, Ilka Hoof, Trevor Hinkley, Mojgan Haddad, Jeannette M Whitcomb, Christos J Petropoulos, Can Keşmir, Sebastian Bonhoeffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22654656/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22654656/?tool=EBI

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