Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.
Human immunodeficiency virus (HIV-1) is, like most pathogens, under selective pressure to escape the immune system of its host. In particular, HIV-1 can avoid recognition by cytotoxic T lymphocytes (CTLs) by altering the binding affinity of viral peptides to human leukocyte antigen (HLA) molecules,...
Main Authors: | Rafal Mostowy, Roger D Kouyos, Ilka Hoof, Trevor Hinkley, Mojgan Haddad, Jeannette M Whitcomb, Christos J Petropoulos, Can Keşmir, Sebastian Bonhoeffer |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS Computational Biology |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22654656/?tool=EBI |
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