Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL

Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL

Previous studies have shown that overexpression of human apolipoprotein C-I (apoC-I) results in moderate hypercholesterolemia and severe hypertriglyceridemia in mice in the presence and absence of apoE. We assessed whether physiological endogenous apoC-I levels are sufficient to modulate plasma lipi...

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Bibliographic Details
Main Authors: Marit Westerterp, Willeke de Haan, Jimmy F.P. Berbeée, Louis M. Havekes, Patrick C.N. Rensen
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein C-I
apolipoprotein E
lipases
transgenic mouse models
lipoprotein lipase
very low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332193

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http://www.sciencedirect.com/science/article/pii/S0022227520332193

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