A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy

A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy

Abstract Background There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unc...

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Bibliographic Details
Main Authors: Laura Gutierrez-Quiceno, Eric B. Dammer, Ashlyn Grace Johnson, James A. Webster, Rhythm Shah, Duc Duong, Luming Yin, Nicholas T. Seyfried, Victor E. Alvarez, Thor D. Stein, Ann C. McKee, Chadwick M. Hales
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Neurodegeneration
Subjects:
Chronic traumatic encephalopathy (CTE)
Tandem mass tagged (TMT)
Proteomics
Frontotemporal dementia (FTD)
Immunoglobulin
Weighted gene co-expression network analysis (WGCNA)
Online Access:https://doi.org/10.1186/s13024-021-00462-3

Internet

https://doi.org/10.1186/s13024-021-00462-3

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