Clinical and Molecular Features of Epidermal Growth Factor Receptor (EGFR) Mutation Positive Non-Small-Cell Lung Cancer (NSCLC) Patients Treated with Tyrosine Kinase Inhibitors (TKIs): Predictive and Prognostic Role of Co-Mutations

Clinical and Molecular Features of Epidermal Growth Factor Receptor (EGFR) Mutation Positive Non-Small-Cell Lung Cancer (NSCLC) Patients Treated with Tyrosine Kinase Inhibitors (TKIs): Predictive and Prognostic Role of Co-Mutations

Background: Tyrosine kinase inhibitors (TKIs) show variable efficacy in epidermal growth factor receptor mutation-positive (EGFR+) NSCLC patients, even in patients harbouring the same mutation. Co-alterations may predict different outcomes to TKIs. Methods: We retrospectively analysed all consecutiv...

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Bibliographic Details
Main Authors: Paolo Bironzo, Maria Lucia Reale, Tessa Sperone, Fabrizio Tabbò, Andrea Caglio, Angela Listì, Francesco Passiglia, Massimo Di Maio, Luisella Righi, Federico Bussolino, Giorgio V. Scagliotti, Silvia Novello
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
epidermal growth factor receptor (EGFR)
non-small-cell lung cancer (NSCLC)
tyrosine kinase inhibitors (TKIs)
co-mutations
next-generation sequencing (NGS)
Online Access:https://www.mdpi.com/2072-6694/13/10/2425

Internet

https://www.mdpi.com/2072-6694/13/10/2425

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