Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine

Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine

Coxiella burnetii, the causative agent of Q fever, is a Gram-negative intracellular bacterium transmitted via aerosol. Regulatory approval of the Australian whole-cell vaccine Q-VAX® in the US and Europe is hindered by reactogenicity in previously exposed individuals. The aim of this study was to id...

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Bibliographic Details
Main Authors: Anja Scholzen, Guilhem Richard, Leonard Moise, Laurie A. Baeten, Patrick M. Reeves, William D. Martin, Timothy A. Brauns, Christine M. Boyle, Susan Raju Paul, Richard Bucala, Richard A. Bowen, Anja Garritsen, Anne S. De Groot, Ann E. Sluder, Mark C. Poznansky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
Coxiella burnetii
Q fever
multi-epitope vaccine
immunoinformatics
IFNγ
T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00207/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00207/full

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