A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells

A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells

We have previously demonstrated that DT-010, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), displays antitumor effects in breast cancer cells both in vitro and in vivo. In the present study, we investigated whether DT-010 enhances the chemotherapeutic effect of doxorubicin (Dox)...

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Bibliographic Details
Main Authors: Liang Wang, Judy Yuet-Wa Chan, Xinhua Zhou, Guozhen Cui, Zhixiang Yan, Li Wang, Ru Yan, Lijun Di, Yuqiang Wang, Maggie Pui-Man Hoi, Luchen Shan, Simon M Y Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Pharmacology
Subjects:
Doxorubicin
Glycolysis
breast cancer
Tetramethylpyrazine
Danshensu
GRP78 protein
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00249/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00249/full

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