MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

Abstract Background MiR-199a-3p (miR-199a) can enhance the chemosensitivity of hepatocellular carcinoma (HCC). Because of the easy degradation of miRNA by direct infusion, effective vehicle-mediated delivery of miR-199a may represent a new strategy for improving HCC chemotherapy. Considering mesench...

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Bibliographic Details
Main Authors: Guohua Lou, Liang Chen, Caixia Xia, Weina Wang, Jinjin Qi, Aichun Li, Liying Zhao, Zhi Chen, Min Zheng, Yanning Liu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mesenchymal stem cell
Exosome
miR-199a-3p
Hepatocellular carcinoma
Chemosensitivity
Online Access:https://doi.org/10.1186/s13046-019-1512-5

Internet

https://doi.org/10.1186/s13046-019-1512-5

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