Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer’s Disease

The impairment of cerebral glucose utilization is an early and predictive biomarker of Alzheimer’s disease (AD) that is likely to contribute to memory and cognition disorders during the progression of the pathology. Yet, the cellular and molecular mechanisms underlying these metabolic alterations re...

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Bibliographic Details
Main Authors: Juliette Piquet, Xavier Toussay, Régine Hepp, Rodrigo Lerchundi, Juliette Le Douce, Émilie Faivre, Elvire Guiot, Gilles Bonvento, Bruno Cauli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glucose uptake
glycolysis
pentose phosphate pathway
FRET imaging
single-cell RT-PCR
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00216/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00216/full

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