New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells

New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells

In this paper, a novel series of imidazole-based heme oxygenase-1 (HO-1) inhibitors is reported. These compounds were obtained by modifications of previously described high potent and selective arylethanolimidazoles. In particular, simplification of the central linker and repositioning of the hydrop...

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Bibliographic Details
Main Authors: Valeria Ciaffaglione, Sebastiano Intagliata, Valeria Pittalà, Agostino Marrazzo, Valeria Sorrenti, Luca Vanella, Antonio Rescifina, Giuseppe Floresta, Ameera Sultan, Khaled Greish, Loredana Salerno
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
heme oxygenase
ho-1
imidazole
inhibitors
structure–activity relationships
anticancer
Online Access:https://www.mdpi.com/1422-0067/21/6/1923

Internet

https://www.mdpi.com/1422-0067/21/6/1923

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