ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

Drebrin is an actin-binding protein known to play a role in neuronal dendritic spines but its precise regulation is unclear. Here, the authors report that DBN is activated by oxidative stress in an ATM-kinase dependent manner and increases resistance to oxidative stress in mice and in C. elegans.

Bibliographic Details
Main Authors: Patricia Kreis, Christian Gallrein, Eugenia Rojas-Puente, Till G. A. Mack, Cristina Kroon, Viktor Dinkel, Claudia Willmes, Kai Murk, Susanne tom-Dieck, Erin M. Schuman, Janine Kirstein, Britta J. Eickholt
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08420-w

Internet

https://doi.org/10.1038/s41467-019-08420-w

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